GENETIC VARIATIONS OF PIP4K2A CONFER VULNERABILITY TO POOR ANTIPSYCHOTIC RESPONSE IN SEVERELY ILL SCHIZOPHRENIA PATIENTS.

Genetic variations of PIP4K2A confer vulnerability to poor antipsychotic response in severely ill schizophrenia patients.

Literature suggests that disease severity and neurotransmitter signaling pathway genes can accurately identify antipsychotic response in schizophrenia patients.However, putative role of signaling molecules has not been tested in schizophrenia patients based on severity of illness, despite its biological plausibility.In the present study we investig

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Research on Cascade Propagation of Collaborative Innovation Risks in Industrial Clusters Considering Entities Heterogeneity

Abstract The objective of this study is to effectively mitigate the cascading propagation of collaborative innovation risks within industrial clusters and bolster the stability of their innovation networks.Drawing upon the cascade failure theory in complex networks, we employ the BA scale-free network model to construct an industrial cluster innova

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Optimal Placement of FACTS Devices Using Modified Whale Optimization Algorithm for Minimization of Transmission Losses

A novel modified whale optimization algorithm (MWOA) is presented in this study to minimize transmission losses.The proposed method is used to determine the best control variables, such as reactive power generation, transformer tap settings, and reactive power sources.First, the power flow analysis method is used to determine where the flexible AC

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Ikaros sets the threshold for negative B-cell selection by regulation of the signaling strength of the AKT pathway

Abstract Inhibitory phosphatases, such as the inositol-5-phosphatase SHIP1 could potentially contribute to B-cell acute lymphoblastic leukemia (B-ALL) by raising the threshold for activation of the autoimmunity checkpoint, allowing malignant cells with strong oncogenic B-cell receptor signaling to escape negative selection.Here, we show that SHIP1

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